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The
free radical-scavenging activity of captopril and ascorbic acid - vitamin C
- was determined by assessing their ability to inhibit the peroxidation of linoleic acid
in sodium dodecyl sulphate (SDS) micelles at 37 degrees C.
The
extent of peroxidation was monitored polarographically using an oxygen electrode to
determine oxygen consumption rates.
Ascorbic
acid - vitamin C - was observed to inhibit the peroxidation in a concentration-dependent
fashion with an IC50 value of 17 microM. In contrast, the addition of captopril at
concentrations up to 500 microM did not result in any detectable inhibition.
Unlike
ascorbic acid, no synergistic effect, as evidenced by the duration of inhibition, was
observed with captopril/alpha-tocopherol mixtures.
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