Vitamin C and Dose-Dependent Protection of Fatty Acids
The free radical-scavenging activity of captopril and ascorbic acid - vitamin C - was determined by assessing their ability to inhibit the peroxidation of linoleic acid in sodium dodecyl sulphate (SDS) micelles at 37 degrees C. 

The extent of peroxidation was monitored polarographically using an oxygen electrode to determine oxygen consumption rates. 

Ascorbic acid - vitamin C - was observed to inhibit the peroxidation in a concentration-dependent fashion with an IC50 value of 17 microM. In contrast, the addition of captopril at concentrations up to 500 microM did not result in any detectable inhibition. 

Unlike ascorbic acid, no synergistic effect, as evidenced by the duration of inhibition, was observed with captopril/alpha-tocopherol mixtures. 33